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During marketing of SARAFEMSNRIsand SSRIsthere have been spontaneous reports of adverse reactions occurring upon discontinuation of these drugsparticularly when abruptincluding the followingdysphoric moodirritabilityagitationdizzinesssensory disturbancesfor exampleparesthesias such as electric shock sensationsanxietyconfusionheadachelethargyemotional labilityinsomniaand hypomaniaWhile these reactions are generally self-limitingthere have been reports of serious discontinuation symptoms.
In children and young adultsthe risks must be weighed against the benefits of taking antidepressants.
Anaphylactoid reactionsincluding bronchospasmangioedemalaryngospasmand urticaria alone and in combinationhave been reported.
1 These terms represent serious adverse reactionsbut do not meet the definition for adverse drug reactionsThey are included here because of their seriousness.
Clinical experience with fluoxetine in patients with concomitant systemic illness is limitedCaution is advisable in using fluoxetine in patients with diseases or conditions that could affect metabolism or hemodynamic responses.
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