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Nausea and vomiting commonly occur with cyclophosphamide therapyAnorexia andless frequentlyabdominal discomfort or pain and diarrhea may occurThere are isolated reports of hemorrhagic colitisoral mucosal ulceration and jaundice occurring during therapyThese adverse drug effects generally remit when cyclophosphamide treatment is stopped.
Hepatic imparimentGive 75of normal dose if transaminase levels are3 times upper limit of normal or bilirubin is 3.1-5 mg/dL.
Tell your doctor right away if any of these rare but very serious side effects occurblack/bloody stoolssevere stomach/abdominal painyellowing eyes or skindark urinemental/mood changesmuscle weakness/spasm.
InfectionsThe following manifestations have been associated with myelosuppression and immunosuppression caused by cyclophosphamideincreased risk for and severity of pneumoniasincluding fatal outcomesother bacterialfungalviralprotozoal andparasitic infectionsreactivation of latent infectionsincluding viral hepatitistuberculosisPneumocystis jiroveciherpes zosterStrongyloidessepsis and septic shock.
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