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Hyperplasia of the biliary tract and cholangioma and adenocarcinoma of the intrahepatic biliary system have been reported in one strain of rats after dietary administration of doses exceeding the maximum tolerated dose for 22 monthsHyperplasticbut not neoplasticlesions were reported at lower dosesSubsequent long-term dietary administration studies in a different strain of rateach with an exposure level equal to the maximum level employed in the earlier experimenthave failed to show such hyperplasticneoplastic changes in the liverNo mutagenic activity has been demonstrated in several in vitro and in vivo test systems.

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A very serious allergic reaction to this drug is rareHoweverseek immediate medical attention if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

1Local fibrinolysisThe recommended standard dosage is 15-25 mg/kg bodyweighti.e2-3 tabletstwo to three times dailyFor the indications listed below the following doses may be used:

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