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The addition of carbidopa with levodopa in the form of SINEMET reduces the peripheral effectsnauseavomitingdue to decarboxylation of levodopahowevercarbidopa does not decrease the adverse reactions due to the central effects of levodopaBecause carbidopa permits more levodopa to reach the brain and more dopamine to be formedcertain adverse central nervous systemCNSeffectse.gdyskinesiasinvoluntary movementsmay occur at lower dosages and sooner with SINEMET than with levodopa alone.
SINEMET should be administered cautiously to patients with severe cardiovascular or pulmonary diseasebronchial asthmarenalhepatic or endocrine disease.
Symptomatic postural hypotension occurred when SINEMET was added to the treatment of a patient receiving antihypertensive drugsThereforewhen therapy with SINEMET is starteddosage adjustment of the antihypertensive drug may be required.
All medicines have risks and benefitsYour doctor has weighed the risks of you taking SINEMET against the benefits they expect it will have for you.
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