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In part b n 24 , subjects were titrated to doxazosin 4 mg administered daily at 8 p.
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Priapismpainful penile erectionsustained for hours and unrelieved by sexual intercourse or masturbationrarely reportedprobably less frequently than once in every several thousand patientswith alpha-1 antagonistsincluding doxazosinbecause condition can lead to permanent impotence if not promptly treatedpatients must be advised about seriousness of condition.
Avoid use for hypertensionhigh risk of orthostatic hypotensionBeers criteriaif usedlower initial dosages and gradual adjustments are recommended.
Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.
Doxazosin is a prescription drug indicated for the treatment of hypertensionto lower blood pressureLowering blood pressure reduces the risk of fatal and nonfatal cardiovascular eventsprimarily strokes and myocardial infarctionsThese benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classesincluding this drug.
Hepatic impairmentUse with caution in mild-to-moderate hepatic dysfunctiondo not use in severe impairment.
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e 36 patients received a dose of 8 mg doxazosin mesylate.
