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This is unusual for a drug like keppra that does not undergo metabolism by the liver.

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KEPPRA tablets should be swallowed wholeKEPPRA tablets should not be chewed or crushed.

Partial-onset seizures with or without generalisation in patients from one month of agemyoclonic seizuresshortshock-like jerks of a muscle or group of musclesin patients from 12 years of age with juvenile myoclonic epilepsyprimary generalised tonic-clonic seizuresmajor fitsincluding loss of consciousnessin patients from 12 years of age with idiopathic generalised epilepsythe type of epilepsy that is thought to have a genetic cause

KEPPRA can cause hematologic abnormalitiesHematologic abnormalities occurred in clinical trials and included decreases in white blood cellWBCneutrophiland red blood cellRBCcountsdecreases in hemoglobin and hematocritand increases in eosinophil countsCases of agranulocytosispancytopeniaand thrombocytopenia have been reported in the postmarketing settingA complete blood count is recommended in patients experiencing significant weaknesspyrexiarecurrent infectionsor coagulation disorders.

Table 3Adverse Reactions in Pooled Placebo-ControlledAdd-On Studies in Adults Experiencing Partial Onset Seizures.

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4 of adult keppra-treated patients experienced coordination difficulties, reported as either ataxia, abnormal gait, or incoordination compared to 1.

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