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Withhold or permanently discontinue XELODA based on clinical assessment of the onsetduration and severity of the observed toxicities in patients with evidence of acute early-onset or unusually severe toxicitywhich may indicate near complete or total absence of DPD activityNo XELODA dose has been proven safe for patients with complete absence of DPD activityThere is insufficient data to recommend a specific dose in patients with partial DPD activity as measured by any specific test.
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