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Promethazine may increase, prolong, or intensify the sedative action of other central nervous system depressants, such as alcohol, sedatives hypnotics including barbiturates , narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine hcl.

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Promethazine can cause side effects that may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be awake and alertAvoid drinking alcoholwhich can increase some of the side effects of promethazineThere are many other medicines that can interact with promethazineTell your doctor about all the prescription and over-the-counter medications you useThis includes vitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start using a new medication without telling your doctorKeep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

OtherAngioneurotic edemaNeuroleptic malignant syndromepotentially fatalhas also been reportedSee WARNINGS-Neuroleptic Malignant Syndrome

Promethazine can cause side effects that may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be awake and alertAvoid drinking alcoholwhich can increase some of the side effects of promethazineThere are many other medicines that can interact with promethazineTell your doctor about all the prescription and over-the-counter medications you useThis includes vitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start using a new medication without telling your doctorKeep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Promethazine should not be used in children younger than 2 years because it may cause seriouspossibly fatalslow/shallow breathingWhen using this medication in children 2 years and olderthe lowest effective dosage should be usedand other drugs that affect breathing should be avoidedGet medical help right away if slow/shallow breathing occurs.

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