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The main part of the estrace vaginal cream is it does not affect any organ of the body system.
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Endometriosis may be exacerbated with administration of estrogensA few cases of malignant transformation of residual endometrial implants have been reported in women treated post-hysterectomy with estrogen alone therapyFor patients known to have residual endometriosis post-hysterectomythe addition of progestin should be considered.
No pharmacokinetic studies were conducted in special populationsincluding patients with renal or hepatic impairment.
Use of ESTRACE alone or in combination with a progestinshould be limited to the shortest duration consistent with treatment goals and risks for the individual womanPostmenopausal women should reevaluate periodically as clinically appropriate to determine if treatment is still necessaryFor treatment of vulvar and vaginal atrophy associated with the menopausethe lowest dose and regimen that will control symptoms should be chosen and medication should be discontinued as promptly as possibleFor women who have a uterusadequate diagnostic measuresincluding directed and random endometrial sampling when indicatedshould be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal genital bleeding.
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