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Corticosteroids may exacerbate systemic fungal infections and therefore should not be used in the presence of such infections unless they are needed to control life-threatening drug reactionsThere have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failuresee PRECAUTIONSDrug InteractionsAmphotericin B injection and potassium-depleting agents
Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody responseCorticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccinesRoutine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possiblesee WARNINGSInfectionsVaccination
Administration of live or liveattenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroidsKilled or inactivated vaccines may be administeredHoweverthe response to such vaccines cannot be predictedImmunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapye.gfor Addison’s disease.
Generic NameDexamethasoneDECKS-uh-METH-uh-zonedexamethasone sodium phosphatedexamethasone acetate Trade NameDecadronDexasoneDiodexHexadrolMaxidex.
Bullous dermatitis herpetiformisexfoliative erythrodermamycosis fungoidespemphigusand severe erythema multiformeStevens-Johnson syndrome
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