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Gabapentin does not exhibit affinity for benzodiazepineopiatemudelta or kappaor cannabinoid 1 receptor sitesA small number of postmarketing cases report gabapentin misuse and abuseThese individuals were taking higher than recommended doses of gabapentin for unapproved usesMost of the individuals described in these reports had a history of poly-substance abuse or used gabapentin to relieve symptoms of withdrawal from other substancesWhen prescribing gabapentin carefully evaluate patients for a history of drug abuse and observe them for signs and symptoms of gabapentin misuse or abusee.gdevelopment of toleranceself-dose escalationand drug-seeking behavior
Get emergency medical help if you have signs of an allergic reaction to Neurontinhivesdifficult breathingswelling of your facelipstongueor throat.
Gabapentin can be removed by hemodialysisAlthough hemodialysis has not been performed in the few overdose cases reportedit may be indicated by the patient’s clinical state or in patients with significant renal impairment.
The following serious adverse reactions are discussed in greater detail in other sections:
Because elderly patients are more likely to have decreased renal functioncare should be taken in dose selectionand dose should be adjusted based on creatinine clearance values in these patients.
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