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Selegiline should also not be used with other drugs which are also monoamine oxidase inhibitorse.glinezolid.
Although serious hepatic toxicity has not been observedcaution is recommended in patients with a history of hepatic dysfunctionTransient or continuing abnormalities with a tendency for elevated plasma concentrations of liver enzymes have been described during long-term therapy with conventional tablets of selegiline.
The extent of systemic exposure to selegiline at a given dose varies considerably among individualsEstimates of systemic clearance of selegiline are not availableFollowing a single oral dosethe mean elimination half-life of selegiline is two hoursUnder steady state conditions the elimination half-life increases to ten hours.
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