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Greater absorption was observed for the temovate gel formulation as compared to the cream formulation in in vitro human skin penetration studies.

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Rarelyit is possible this medication will be absorbed from the skin into the bloodstreamThis can lead to side effects of too much corticosteroidThese side effects are more likely in childrenand in people who use this medication for a long time or over large areas of the skinTell your doctor right away if any of the following side effects occurunusual/extreme tirednessweight lossheadacheswelling ankles/feetincreased thirst/urinationvision problems.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you toIf you are treating the diaper area of a babydo not use plastic pants or tight-fitting diapersCovering the skin that is treated with clobetasol topical can increase the amount of medicine your skin absorbswhich may lead to unwanted side effectsFollow your doctor’s instructions.

Every effort has been made to ensure that the information provided by Cerner MultumIncMultumis accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveMultum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseMultum’s drug information does not endorse drugsdiagnose patients or recommend therapyMultum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safeeffective or appropriate for any given patientMultum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum providesThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have questions about the drugs you are takingcheck with your doctornurse or pharmacist.

Jay WMarksMDis a board-certified internist and gastroenterologistHe graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

If HPA axis suppression is notedan attempt should be made to withdraw the drugto reduce the frequency of applicationor to substitute a less potent corticosteroidRecovery of HPA axis function is generally prompt upon discontinuation of topical corticosteroidsInfrequentlysigns and symptoms of glucocorticosteroid insufficiency may occur that require supplemental systemic corticosteroidsFor information on systemic supplementationsee prescribing information for those products.

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