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Patients, therefore, should be warned against excessive alcohol intake, acute or chronic, while receiving actoplus met.

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Tak th mdicin as soon as you can, but skip th missd dos i it is almost tim you nxt dos. Dnot tak twdoss at on tim.

Actoplus Mt contains a combination mtomin and pioglitazon, twoal diabts mdicins that hlp contol blood suga lvls.

Clinical studis dmonstat that pioglitazon impovs insulin snsitivity in insulin-sistant patints. Pioglitazon nhancs cllula sponsivnss tinsulin, incass insulin-dpndnt glucos disposal and impovs hpatic snsitivity tinsulin. In patints with typ 2 diabts, th dcasd insulin sistanc poducd by pioglitazon sults in low plasma glucos concntations, low plasma insulin concntations, and low HbA1c valus. In contolld clinical tials, pioglitazon had an additiv ct on glycmic contol whn usd in combination with a sulonylua, mtomin, insulin [s Clinical Studis ].

Us mtomin in patints with hpatic impaimnt has bn associatd with som cass lactic acidosis; thapy is not commndd in patints with hpatic impaimnt.

Masu liv tsts pomptly in patints whpot symptoms that may indicat liv injuy, including atigu, anoxia, ight upp abdominal discomot, dak uin jaundic. In this clinical contxt, i th patint is ound thav abnomal liv tsts (ALT gat than th tims th upp limit th nc ang), ACTOPLUS MT tatmnt should b intuptd and invstigation don tstablish th pobabl caus. ACTOPLUS MT should not b statd in ths patints without anoth xplanation th liv tst abnomalitis.

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