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The efficacy of abilify as monotherapy in the acute treatment of manic episodes was established in four 3-week, placebo-controlled trials in hospitalized patients who met the dsm-iv criteria for bipolar i disorder with manic or mixed episodes.
Information about Abilify.
Otsuka America, the company that manufactures Abilify, claims the medication restores balance for patients with mental disorders, working in much the same way as a thermostat. But according to the U.S. Food and Drug Administration (FDA), the way the medication works is still unknown.
Abilify can also cause metabolic problems, including hyperglycemia (high blood sugar and diabetes. In extreme cases, these problems can cause comas and even death. Symptoms of metabolic problems include feeling thirsty, hungry, tired, or weak, experiencing an increased need to urinate, feeling sick; and feeling confused.
Certain individuals may face additional or increased risks when using prescription drugs. Risks of Abilify for specific populations include:
Cerebrovascular Adverse Reactions in Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse reactions (e.g. stroke, transient ischemic attack, including fatalities). Neuroleptic Malignant Syndrome: Manage with immediate discontinuation and close monitoring. Tardive Dyskinesia: Discontinue if clinically appropriate. Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain. Hyperglycemia/Diabetes Mellitus: Monitor glucose regularly in patients with and at risk for diabetes. Dyslipidemia: Undesirable alterations in lipid levels have been observed in patients treated with atypical antipsychotics. Weight Gain: Weight gain has been observed with atypical antipsychotic use. Monitor weight. Pathological Gambling and Other Compulsive Behaviors: Consider dose reduction or discontinuation. Falls: Antipsychotics may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls. Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope. Leukopenia, Neutropenia, and Agranulocytosis: have been reported with antipsychotics including ABILIFY. Patients with a history of a clinically significant low white blood cell count (WBC or a drug-induced leukopenia/neutropenia should have their complete blood count (CBC monitored frequently during the first few months of therapy and discontinuation of ABILIFY should be considered at the first sign of a clinically significant decline in WBC in the absence of other causative factors. Seizures/Convulsions: Use cautiously in patients with a history of seizures or with conditions that lower the seizure threshold. Potential for Cognitive and Motor Impairment: Use caution when operating machinery. Suicide: The possibility of a suicide attempt is inherent in schizophrenia and bipolar disorder. Closely supervise high-risk patients.
The FDA approved the first generic versions of Abilify two years ago, and Gellad predicts that the daily generic is going to be much less expensive than this one with the sensor.
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