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Latanoprost is a colorless to slightly yellow oil that is very soluble in acetonitrile and freely soluble in acetoneethanolethyl acetateisopropanolmethanoland octanolIt is practically insoluble in water.
Results showed that the onset of noticeable increased iris pigmentation occurred within the first year of treatment for the majority of the patients who developed noticeable increased iris pigmentationPatients continued to show signs of increasing iris pigmentation throughout the five years of the studyObservation of increased iris pigmentation did not affect the incidencenatureor severity of adverse eventsother than increased iris pigmentationrecorded in the studyIOP reduction was similar regardless of the development of increased iris pigmentation during the study.
If more than one topical ophthalmic medicinal product is being usedthe medicinal products should be administered at least five minutes apart.
Latanoprost was not mutagenic in bacteriain mouse lymphomaor in mouse micronucleus testsChromosome aberrations were observed in vitro with human lymphocytesAdditional in vitro and in vivo studies on unscheduled DNA synthesis in rats were negative.
Table 2Adverse Reactions That Were Reported in 1-5of Patients Receiving Latanoprost.
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