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NSAIDsincluding Ponstelcan lead to new onset of hypertension or worsening of pre-existing hypertensioneither of which may contribute to the increased incidence of CV eventsPatients taking angiotensin converting enzymeACEinhibitorsthiazides diureticsor loop diuretics may have impaired response to these therapies when taking NSAIDssee PRECAUTIONSDrug Interactions
Do not drink alcohol while taking mefenamic acidAlcohol can increase the risk of stomach bleeding.
A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polypsseverepotentially fatal bronchospasmand/or intolerance to aspirin and other NSAIDsBecause cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patientsPonstel is contraindicated in patients with this form of aspirin sensitivitysee CONTRAINDICATIONSWhen Ponstel is used in patients with pre-existing asthmawithout known aspirin sensitivitymonitor patients for changes in the signs and symptoms of asthma.
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in april 2000, we also entered into a supply agreement with pfizer under which pfizer was to supply us with designated quantities of ponstel through the expiration of the supply agreement which occurred on march 31, 2001.
