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For which conditions is this drug approvedFlutamide is approved for the treatment of stage D2 prostate cancerwhere cancer has spread from its site of origin to different sites in the bodyIt is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDAPatients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.
HOW TO USERead the Patient Information Leaflet provided by your pharmacist before you start using flutamide and each time you get a refillIf you have any questionsconsult your doctor or pharmacist.Take this medication by mouth with or without foodusually 3 times daily or as directed by your doctor.Dosage is based on your medical condition and response to therapy.Use this medication regularly to get the most benefit from itTo help you remembertake it at the same times each dayDo not stop any medications for your prostate cancer unless told to do so by your doctorStopping your medications could allow the cancer to spread more rapidly.Tell your doctor if your condition persists or worsenssuch as urination becomes more difficultbone pain increases
Call your doctor if you have severe or ongoing diarrheaYour doctor may recommend an anti-diarrhea medicine.
Serum transaminase levels should be measured prior to starting treatment with flutamideFlutamide is not recommended in patients whose ALT values exceed twice the upper limit of normalSerum transaminase levels should then be measured monthly for the first 4 months of therapyand periodically thereafterLiver function tests also should be obtained at the first signs and symptoms suggestive of liver dysfunctionegnauseavomitingabdominal painfatigueanorexiaflu-likesymptomshyperbilirubinuriajaundiceor right upper quadrant tendernessIf at any time a patient has jaundiceor their ALT rises above 2 times the upper limit of normalflutamide should be immediately discontinued with close follow-up of liver function tests until resolution.
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